منابع مشابه
Langerhans Cells in Skin Lesions of Leprosy
Background: Langerhans cells are important in the pathogenesis of leprosy. A recent study reported that these cells were almost absent in the epidermis overlying lepromatous lesions. Objective: To investigate a possible relationship between the number of Langerhans cells and the histopathologic spectrum of lesions in patients with leprosy. Methods: An immunohistochemical staining for S100 prot...
متن کاملLangerhans cells and the cells of Langerhans cell histiocytosis do not express DC-SIGN.
vasculitic lesions. Cell-mediated immune (CMI) dysfunction, including defective natural killer cell function has been documented in patients with XLP, and defective CMI may result in altered EBV tissue tropism as we suggest. We agree that many more patients, as well as controls, would need to be studied to definitively answer this issue. The functionality of EBV-specific CTL remains a subject f...
متن کاملDifferentiation of Langerhans cells in Langerhans cell histiocytosis.
Langerhans cell histiocytosis (LCH) consists of lesions composed of cells with a dendritic Langerhans cell (LC) phenotype. The clinical course of LCH ranges from spontaneous resolution to a chronic and sometimes lethal disease. We studied 25 patients with various clinical forms of the disease. In bone and chronic lesions, LCH cells had immature phenotype and function. They coexpressed LC antige...
متن کاملlangerhans cells in skin lesions of leprosy
background: langerhans cells are important in the pathogenesis of leprosy. a recent study reported that these cells were almost absent in the epidermis overlying lepromatous lesions. objective: to investigate a possible relationship between the number of langerhans cells and the histopathologic spectrum of lesions in patients with leprosy. methods: an immunohistochemical staining for s100 ...
متن کاملLangerhans Cells—Programmed by the Epidermis
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances. In a normal physiological, "non-dangerous" situation, LCs coordinate a continuous state of immune tolerance, preventing u...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1980
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12543533